Alexandria, VA, USA – A study aiming to use a novel transgenic mouse model (TTP knock-in – TTPKI) that has a moderate elevation of TTP systemically to understand if there is a long-term benefit for bone health, thus contributing towards healthy aging was presented at the 102nd General Session of the IADR, which was held in conjunction with the 53rd Annual Meeting of the American Association for Dental, Oral, and Craniofacial Research and the 48th Annual Meeting of the Canadian Association for Dental Research, on March 13-16, 2024, in New Orleans, LA, USA.
The abstract, “Enhanced Stability of Tristetraprolin Promotes Bone Health and Reduces Frailty” was presented during the “Systemic Conditions and Diseases and Oral Health Status” Poster Session that took place on Thursday, March 14, 2024 at 11 a.m. Central Standard Time (UTC-6).
The study, by Lixia Zhang of the University at Buffalo, NY, USA, performed body composition, physical performance assessments, and frailty assessments on the 6- and 22-month-old TTPKI and C57BL/6N wild-type male and female mice. Microcomputed tomography (µCT) and decalcified sections of the tibia were used to determine static bone histomorphometric paraments and bone histomorphometry, respectively. Immunophenyptoc analysis of bone marrow (BM), spleen, and mesenteric lymph nodes were analyzed by flow cytometry for myeloid and lymphocyte populations. Myeloid population BM osteoclastogenic potential was assessed.
Body composition with aged control and TTPKI mice revealed significant sex and genotype differences. Aged TTPKI mice displayed decreased frailty scores and increased quality of life compared to control similarly aged mice. The tibia from aged TTPKI mice exhibited higher BMD than aged control mice. Age-related decline in immune cell composition was partially reversed in aged TTPKI mice. In an osteoclast differentiation assay, BM myeloid progenitors from TTPKI mice exhibited fewer osteoclasts with reduced eroded bone surface area. Improved functional capacity, BMD, and immune cell composition indicate that enhanced expression of TTP can promote a healthier phenotype during aging.
About IADR
The International Association for Dental, Oral, and Craniofacial Research (IADR) is a nonprofit organization with a mission to drive dental, oral, and craniofacial research for health and well-being worldwide. IADR represents the individual scientists, clinician-scientists, dental professionals, and students based in academic, government, non-profit, and private-sector institutions who share our mission. Learn more at www.iadr.org.
About AADOCR
The American Association for Dental, Oral, and Craniofacial Research (AADOCR) is a nonprofit organization with a mission to drive dental, oral, and craniofacial research to advance health and well-being. AADOCR represents the individual scientists, clinician-scientists, dental professionals, and students based in academic, government, non-profit, and private-sector institutions who share our mission. AADOCR is the largest division of IADR. Learn more at www.aadocr.org.